Research Associate in vivo gene therapy in Rare Blood Disorders (m/f/d)

Beschreibung

We are looking for a motivated and committed Research Associate in vivo gene therapy in Rare Blood Disorders  for our client, F. Hoffmann-La Roche Ltd. based in Basel, for a 18 month assignment with the option to extend.

In the Immunology group, we are developing cutting edge therapies to treat rare blood disorders. As a member of Immunology, you will be part of a highly collaborative, international group of research associates and scientists that are developing medicines for the future.

We're currently looking for a research associate to assess efficacy, safety and translatability of gene therapies in rare blood disorders (bleeding/thrombotic disorders, anemia, etc..) by using different in vivo and ex vivo assays. Together with a larger team you will work with preclinical animal models and human patient material (blood and plasma) and characterize different gene therapy assets in hemostasis and thrombosis.  The ex vivo and in vivo approaches will require you to be skilled in end-to-end experiments from the hands-on animal study, sample collection to different ex vivo assays.

Tasks

• Executing diverse in vivo experiments (i.v. injections, blood and plasma collection, bleeding and thrombosis models or similar) and managing necessary animal welfare requirements (LTK1)
• Characterizing efficacy and safety of novel gene therapy assets using molecular and biochemical techniques (ELISA, Thrombin generation assay, chromogenic assays, etc) in murine and human samples
• Preparation, handling and in vitro/ex vivo testing and analysis of patient-derived material, including blood and plasma
• Collaborating on the development of new experimental strategies and custom assays  with our research scientists
• General lab management and organization, incl. maintenance, safety, inventory, etc.
• Contributing to data analysis and communicating results to the team
• Taking and maintaining detailed documentation of data

Must Haves

• MSc/BSc in Life Sciences (cellular/ molecular biology, pharmacology, immunology), or completion of an apprenticeship for a research associate (“Lehrabschluss”) with ≥ 3 years of academic or industry experience
• Allowance to conduct animal experimentation (active LTK1, FELASA or equivalent) and experience with rodents is necessary, including intravenous injections and blood collection is required, surgery experience is a plus
• Extensive mouse work experience
• High motivation, flexibility, and excellent organizational skills to support our team
• You can communicate fluently in English
• Open and collaborative spirit
• Vigorous “can do” mentality to succeed in a dynamic and highly collaborative research team

Are you interested? Don't hesitate and send us your complete application documents online today.

We will also process applications by post, but will not return them for administrative reasons. We look forward to hearing from you!